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KMID : 0988920140120020146
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Intestinal Research
2014 Volume.12 No. 2 p.146 ~ p.152
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Does Diabetes Mellitus Influence Standardized Uptake Values of Fluorodeoxyglucose Positron Emission Tomography in Colorectal Cancer?
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Oh Da-Yeon
Kim Ji-Won
Koh Seong-Joon
Kim Min-Goo
Park Ji-Hoon
Cho Su-Yeon
Kim Byeong-Gwan
Lee Kook-Lae
Im Jong-Pil
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Abstract
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Background/Aims: Hyperglycemia is associated with decreased 2-18[F]fluoro-2-deoxy-D-glucose (FDG) uptake by tumorsassessed by positron emission tomography (PET). In this retrospective study we investigated a comparison of standardizeduptake values (SUVs) in patients with primary colorectal cancers who either had diabetes mellitus (DM) or were otherwisehealthy.
Methods: The medical records of 397 patients who were diagnosed with colorectal cancer and underwent PETCTbetween January 2006 and December 2012 were analyzed. Eighty patients with DM and 317 patients without DM wereincluded. Clinical characteristics were reviewed and maximal standardized uptake values (SUVmax) were calculated in the primarycolorectal lesions.
Results: There was no significant difference between tumor SUVmax in DM patients (10.60±5.78) andthose without DM (10.92±5.44). In addition, no significant difference was detected between tumor SUVmax in DM patients withglycated hemoglobin (HbA1c) levels <8% (10.34±5.17) and those with HbA1c levels ≥8% (10.61±7.27). The maximum size ofthe primary colorectal tumor was associated with SUVmax in a linear regression analysis.
Conclusion: The results of this studyshowed that DM did not influence FDG uptake values in colorectal cancer patients regardless of glucose levels. (Intest Res2014;12:146-152)
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KEYWORD
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Diabetes mellitus, Positron emission tomography, Colorectal neoplasms
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